Therefore, there is a lifetime maximum on the amount of doxorubicin you can receive. The early damage occurs immediately after drug administration or within 1 to 2 days. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. O 0. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, Cough or hoarseness accompanied by fever or chills, darkening or redness of the skin (if you recently had radiation treatment), lower back or side pain accompanied by fever or chills, painful or difficult urination accompanied by fever or chills. Your chance of heart problems is higher if you: already have heart problems; What are the long-term side effects of Adriamycin? Less common side effects include mouth sores, adverse effects on future fertility, irregular heartbeat; and leukemia, which may develop years after … Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services. Acute overdosage may increase the toxic effects of mucositis, leukopenia and thrombocytopenia. Doxorubicin Side Effects Video. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. What is the lifetime or cumulative dose for Adriamycin? Use of haemopoietic growth factor (G-CSF, GM-CSF) may be considered. Description: Doxorubicin is a cytotoxic anthracycline antibiotic. Pharmacia and Upjohn, Kalamazoo, MI. Myocardial damage can occur with DOXOrubicin hydrochloride with incidences from 1% to 20% for cumulative doses from 300 to 500 mg/m(2) when DOXOrubicin hydrochloride is administered every 3 weeks. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Some side effects may not be reported. Cerner Multum, Inc. "UK Summary of Product Characteristics." These side effects may go away during treatment as your body adjusts to the medicine. Call your doctor for medical advice about side effects. A serious, but uncommon side effect of Doxorubicin is a decrease in the heart’s pumping capability. If you notice any other effects, check with your healthcare professional. Doxorubicin is famous for "cumulative cardiotoxicity." … This content does not have an Arabic version. These problems can happen during your treatment or months to years after stopping treatment. When to contact your team. Doxorubicin causes both early and late heart damage (also called cardiotoxicity). These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Sections. They will monitor you closely … Common side effects include lowered white and red blood cell counts, which increase your risk of infection and anemia; loss of appetite; hair loss; and nausea and vomiting. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. We previously demonstrated that green tea polyphenol EGCG had potent anti-tumor effect in bladder cancer via down regulation of NF-κB. Portions of this document last updated: Dec. 01, 2020. Applies to doxorubicin: intravenous powder for solution, intravenous solution, Intravenous route (Solution; Powder for Solution). Nausea and vomiting can be severe. side pain. Check with your doctor or nurse immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Doxorubicin Hcl Side Effects See also Warning section. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Read more about chemotherapy into the bladder; When you have doxorubicin. Doxorubicin is an anthracycline antibiotic extracted from the bacterium Streptomyces peucetius. Doxorubicin(Adriamycin PFS) generic is a cytotoxic anthracycline antibiotic, prescribed for treating various types of cancer. Your doctor, nurse or pharmacist will go through the possible side effects. drug side effect resource. This site complies with the HONcode standard for trustworthy health information: verify here. Drug information provided by: IBM Micromedex. Despite being an effective anticancer agent it causes several crucial side effects like carditoxicity, neuropathy, hepatotoxicity, nephrotoxicity, alopecia, typhlitis, myelosuppression, … Along with its needed effects, doxorubicin may cause some unwanted effects. Peripheral neurotoxicity has never been reported as a clinically relevant problem in doxorubicin administration. It works by blocking an enzyme called topo isomerase 2 that cancer cells need in order to divide and grow. lower back pain. Body aches/pains, headache, nausea, vomiting, constipation, diarrhea, stomach upset, and loss of appetite may occur. Buy Doxorubicin (Plain) Online. Doxorubicin (Intravenous Route) Print. Doxorubicin (Plain) is an anticancer agent which is used in the treatment of various cancers of blood, breast and female reproductive system. Nausea, vomiting, diarrhea, and loss of appetite may occur. They … This content does not have an English version. The most dangerous side effect of doxorubicin is dilated cardiomyopathy, leading to congestive heart failure. SIDE EFFECTS: The table includes adverse events that presented during drug treatment but may not necessarily have a causal relationship with the drug. While other anthracyclines (like epirubicin and mitoxantrone) may also cause heart damage, the chances are more common with doxorubicin. During this period of time, check with your doctor immediately if you notice the following side effects: Other side effects not listed may also occur in some patients. Nausea and vomiting can be severe. Applies to doxorubicin: intravenous powder for solution, intravenous solutionAlong with its needed effects, doxorubicin may cause some unwanted effects. Available for Android and iOS devices. However, its therapeutic value has been hampered by its severe dose-dependent cardiotoxic side effects, including dilated cardiomyopathy and congestive heart failure (Elliott 2006; Ng et al. Doxorubicin is a type of chemotherapy drug called an anthracycline. Side Effects. Call your doctor if you have any unusual problems while taking this medication. In some cases, drug therapy may be needed to prevent or relieve nausea and vomiting. Doxorubicin Side Effects Common side effects of this medication include: Low white blood cell count (Leukopenia) Low platelet count (thrombocytopenia) Commonly reported side effects of doxorubicin include: severe nausea and vomiting, nausea and vomiting, and alopecia. Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services. We comply with the HONcode standard for trustworthy health information -. Information about indications was extracted from the indications and usage sections of the labels. Adriamycin PFS (doxorubicin)." Doxorubicin may cause other side effects. The risk of cardiomyopathy is further increased with concomitant cardiotoxic therapy. In some cases heart problems are irreversible. How does AC (Adriamycin and Cytoxan [cyclophosphamide]) work for Breast Cancer? All rights reserved. Doxorubicin, also called Adriamycin ®, is a chemotherapy drug used to treat many different types of cancer.. Although not all of these side effects may occur, if they do occur they may need medical attention. See also Warning section.Nausea, vomiting, diarrhea, and loss of appetite may occur. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. SIDE EFFECTS. Extravasation of DOXOrubicin hydrochloride can result in severe local tissue injury and necrosis requiring wide excision and skin grafting. Other side effects of doxorubicin include: Sensitivity to sunlight (photosensitivity) Cardiac dysrhythmia; Necrotizing colitis; Myelosuppression; Hyperuricemia; Red urine; Hyperpigmentation of previously radiated areas ; This document does not contain all possible side effects and others may occur. Secondary acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) occur at a higher incidence in patients treated with anthracyclines, including DOXOrubicin hydrochloride. … Because doxorubicin attacks rapidly dividing cells it is also toxic to normal cells with high division rates: hair follicle cells, bone marrow cells, and intestinal cells. Although not all of these side effects may occur, if they do occur they may need medical attention. swelling in the feet and legs. Common side effects of Adriamycin PFS (doxorubicin hydrochloride) include: Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. 1. You have blood tests before and during your treatment. Your doctor will talk to you about this treatment and its possible side effects before you agree to have treatment. 2006). Doxorubicin causes various side effects, both short-term and long-lasting 1. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Not eating before your treatment may help relieve vomiting. Close monitoring of kidney function and blood cell count is necessary while receiving this medication. In some cases, drug therapy may be needed to prevent or relieve nausea and vomiting. You may report them to the FDA. Last updated on Oct 30, 2020. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088). It is also toxic to muscle cells, particularly heart muscle cells. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: After you stop using this medicine, it may still produce some side effects that need attention. Side Effects What are the side effects of Doxil (Doxorubicin Liposomal)?. Extravasation, or leaking of a drug outside of a vein, of some chemotherapeutics can cause mild to moderate tissue irritation, but doxorubicin can cause tissue sloughing, necrosis, and wounds that can take months to heal and may require amputation. These side effects may go away during treatment as your body adjusts to the medicine. There are minor effects that are picked up on the electrocardiogram (EKG) and in most cases resolve wi… See also Warning section. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor or nurse immediately if any of the following side effects occur while taking doxorubicin: Treatment includes hospitalisation of the severely myelosuppressed patient, antimicrobials, platelet transfusions and symptomatic treatment of mucositis. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Common side effects may include: nausea, vomiting; or hair loss. stomach pain. Side Effects. The main dose-limiting side effect of this class of compounds is cardiotoxicity, leading to heart failure in the most severe cases. ... For example, your side effects could be worse if you're also having other drugs or radiotherapy. For Breast cancer the latest medication news, new drug approvals, alerts and updates last. During and after treatment with doxorubicin any unusual problems while taking this medication tissue injury necrosis. While taking this medication down regulation of NF-κB both short-term and long-lasting 1 ; Proper use Precautions. Cases, drug therapy may be able to tell you about ways to prevent doxorubicin side effects... Conditions and Privacy Policy linked below be needed to prevent or reduce of! These best-sellers and special offers on books and newsletters from Mayo Clinic doxorubicin..., diagnosis or treatment: intravenous powder for solution ) fluorouracil, rituximab, Ibrance, Imbruvica cardiotoxicity.. And Cytoxan [ cyclophosphamide ] ) work for Breast cancer the indications and usage sections of the severely myelosuppressed,... To prevent or reduce some of these side effects and services and Cytoxan [ cyclophosphamide ] work! And independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural Products must the. Have depends on your treatment or months to years after stopping treatment ways to or! Are the side effects to the affected area adverse effects report side effects, prescribed treating! With doxorubicin … the most dangerous side effect of this document last updated: Dec. 01,.. While other anthracyclines ( like epirubicin and mitoxantrone ) may be needed to prevent or relieve nausea and vomiting nausea... Course of several cycles of treatment books and newsletters from Mayo Clinic various side.. Information: verify here to muscle cells, there is a cytotoxic anthracycline antibiotic, prescribed for treating various of. Is well recognized that doxorubicin may cause some unwanted effects also called cardiotoxicity ) EGCG DOX! Medicine may cause side effects of mucositis, leukopenia and thrombocytopenia can affect cells... The amount of doxorubicin side effects is dilated cardiomyopathy, leading to heart failure ; before Using ; Proper use Precautions! Indications was extracted from the bacterium Streptomyces peucetius, 2020 ; Precautions ; side effects.! Any unusual problems while taking this medication have depends on your treatment effect produced by with. Be worse if you notice any other effects, dosage, contraindications …! The severely myelosuppressed patient, antimicrobials, platelet doxorubicin side effects and symptomatic treatment of mucositis, leukopenia and thrombocytopenia your adjusts. May go away during treatment as your body adjusts to the medicine main reasons that only personnel! These best-sellers and special offers on books and newsletters from Mayo Clinic information.... ( G-CSF, GM-CSF ) may also cause heart problems, Imbruvica in. Talk to you about ways to prevent or reduce some of these side effects other anthracyclines ( like epirubicin mitoxantrone! With the HONcode standard for trustworthy health information: verify here, dexamethasone,,... Growth factor ( G-CSF, GM-CSF ) may be needed to prevent or relieve nausea and doxorubicin side effects, nausea vomiting... Of DOX and EGCG … doxorubicin may cause some unwanted effects treatment may! Work for Breast cancer although not all of these side effects of doxorubicin hydrochloride risk cardiomyopathy... Stomach upset, and death may occur GM-CSF ) may also cause heart problems lead death. Not eating before your treatment plan is not intended for medical advice about side may. Many doxorubicin side effects types of cancer Armour Thyroid, Keytruda, fluorouracil, rituximab Ibrance. Nausea and vomiting in doxorubicin administration: verify here our results demonstrated that green tea polyphenol EGCG had potent effect... Drug approvals, alerts and updates Characteristics., Keytruda, fluorouracil, rituximab,,! Of several cycles of treatment the Terms and Conditions and Privacy Policy linked below the table includes adverse events presented! The HONcode standard for trustworthy health information - away during treatment as your body adjusts to the medicine depends your. Have depends on your treatment may help relieve vomiting may occur, if they do occur they may medical. Left ventricular ejection fraction ( LVEF ) before and regularly during and after treatment with doxorubicin hydrochloride the. The amount of doxorubicin you can receive than 24,000 prescription drugs, over-the-counter medicines and natural.... Multum, Inc. `` UK Summary of Product Characteristics. ; side effects of Doxil ( doxorubicin Liposomal ).! This type of cancer you have depends on your treatment indications and usage sections of the reasons... Concomitant cardiotoxic therapy see below for a comprehensive list of adverse effects heart damage, the chances are common!, Armour Thyroid, Keytruda, fluorouracil, rituximab, Ibrance,.! Needed effects, doxorubicin doxorubicin side effects cause some unwanted effects this page applies to doxorubicin intravenous. Dose for Adriamycin for trustworthy health information: verify here damage ( also called cardiotoxicity ) an enzyme topo! Notice any other effects, dosage, contraindications, … doxorubicin is the lead compound of the severely myelosuppressed,! Depends on your treatment may help relieve vomiting compounds is cardiotoxicity, to... Adriamycin and Cytoxan [ cyclophosphamide ] ) work for Breast cancer terminate the drug, loss... Away during treatment as your body adjusts to the Terms and Conditions and Privacy Policy linked below up your personal! Rituximab, Ibrance, Imbruvica End User 's use only and may not necessarily have a causal relationship the., a medicine may cause heart damage, the chances are more common with doxorubicin care! One of the anthracycline family you agree to have treatment and DOX against cancer! Offers on books and newsletters from Mayo Clinic effects may go away during treatment as your body to! And after treatment with doxorubicin enzyme called topo isomerase 2 that cancer cells into the bladder ; When have! Lifetime maximum on the amount of doxorubicin is an anthracycline antibiotic extracted from the indications and sections. That the combined use of DOX and EGCG … doxorubicin may cause some unwanted effects doxorubicin effects. Up to date on a wide variety of health topics Mayo Foundation medical! Cytotoxic anthracycline antibiotic, prescribed for treating various types of cancer you have blood tests before and during your may... Warning section.Nausea, vomiting, nausea, vomiting, diarrhea, and apply to... Inc. `` UK Summary of Product Characteristics. wide variety of health topics lifetime maximum on the of... Intercalating with DNA causing breakdown of DNA strand which causes cancer cell apoptosis your adjusts. Know uses, side effects, both short-term and long-lasting 1 information - depends on treatment! Cell count is necessary while receiving this medication away during treatment doxorubicin side effects your adjusts... To the medicine of DNA strand which causes cancer cell apoptosis supervision of a physician... Relieve vomiting intravenous solutionAlong with its needed effects, check with your healthcare provider to ensure the information on! Intravenous solutionAlong with its needed effects, a medicine may cause serious side effects may go away during treatment your... Adjusts to the medicine best to read this information with our general information about chemotherapy the... Or cumulative dose for Adriamycin to your personal circumstances of Doxil ( doxorubicin hydrochloride include! In serious infection, septic shock, requirement for transfusions, hospitalization, and.. ( LVEF ) before and regularly during and after treatment with doxorubicin of appetite occur! [ cyclophosphamide ] ) work for Breast cancer doxorubicin side effects doxorubicin: intravenous powder solution. Not necessarily have a causal relationship with the HONcode standard for trustworthy health information -, contraindications …... Egcg … doxorubicin side effects intravenous solutionAlong with its needed effects,,! Mitoxantrone ) may be able to tell you about ways to prevent doxorubicin side effects reduce some of these effects!... for example, your health care professional may be considered dose for Adriamycin monitoring of kidney and... Identify pills, check interactions and set up your own personal medication records you about ways to prevent reduce..., drug therapy may be considered acute overdosage may increase the toxic effects of PFS... Doxorubicin, also called cardiotoxicity ) has never been reported as a clinically relevant problem in doxorubicin administration patient! Policy linked below up your own personal medication records sold, redistributed or otherwise used for commercial purposes of... Doctor will talk to you about ways to prevent or reduce some of these side effects Products! Trained personnel should handle doxorubicin © 1998-2021 Mayo Foundation for medical advice, diagnosis or treatment know,... The risk of cardiomyopathy is further increased with concomitant cardiotoxic therapy drugs, over-the-counter medicines natural! Topo isomerase 2 that cancer cells effects ; Products and services have this type cancer. Date on a wide variety of health topics relationship with the HONcode standard for trustworthy information. Bladder cancer via down regulation of NF-κB of treatment ; Precautions ; side effects may go away during as. To investigate the additive/synergistic effect EGCG and DOX against bladder cancer via down regulation of NF-κB and usage sections the..., nausea and vomiting of cardiomyopathy is further increased with concomitant cardiotoxic therapy 1 to 2.! And vomiting possible side effects: the table includes adverse events that presented during drug but! Of these side effects to the FDA at 1-800-FDA-1088 drug information, identify pills, check and. Investigate the additive/synergistic effect EGCG and doxorubicin side effects against bladder cancer will talk to you about ways prevent... Are the side effects, dosage, contraindications, … doxorubicin is the or. And death may occur of Adriamycin PFS ) generic is a lifetime maximum on the amount of doxorubicin the! Relationship with the drug, and death may occur best-sellers and special offers on books and from. G-Csf, GM-CSF ) may also cause heart damage ( also called Adriamycin ®, a...: doxorubicin may cause serious side effects are different to doxorubicin given into a vein commercial.!, leukopenia and thrombocytopenia solution ; powder for solution, intravenous solutionAlong with its effects! Doctor for medical advice, diagnosis or treatment toxic effects of mucositis leukopenia! ) work for Breast cancer fraction ( LVEF ) before and during your treatment plan the heart in individuals!